RNA Viruses and Neurological Disorders

Sabyasachi Dash (Weill Cornell Medicine, NY, USA)

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English

CRC Press
11 December 2023

Infectious & contagious diseases; Neurology & clinical neurophysiology; Pathology

This volume is an accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system (CNS). Chapters cover the major RNA viruses, their impact on the CNS, and the similarities and differences in pathological outcomes that can be observed. Neuroscientists, be they students, researchers, or clinicians, will benefit from the timely coverage provided.

Our understanding of viruses, and specifically RNA viruses and their pathological impact, is rapidly evolving. For example, the close molecular interaction of viruses with the CNS cell types in the human host is poorly understood. Readers can use the book to understand clearly the cellular and molecular mechanisms governing pathological outcomes of RNA virus infection in the cell types of the human brain (e.g., neurons, endothelial cells, astrocytes, resident immune cells) based on summarized case studies, and gain insight into how cell type-specific defects affect brain function and cause poor clinical outcomes.

The book is aimed primarily at neuroscience students and postgraduates wishing to learn about virology and professionals who are interested to learn more about virus-associated neuropathology. A basic knowledge of cell and molecular biology is assumed; however, readers across the disciplines of science, technology, engineering, and mathematics will find this topical and timely publication of value.

Edited by: Sabyasachi Dash (Weill Cornell Medicine NY USA)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 480g
ISBN: 9781032259567
ISBN 10: 1032259566
Pages: 250
Publication Date: 11 December 2023
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Paperback
Publisher's Status: Active

Chapter 1: Structure and Classification of RNA viruses Chapter 2: RNA viruses with CNS tropism Chapter 3: Common Neuropathological features of RNA viruses Chapter 4: Molecular and cellular alterations underlying neurological outcomes in HIV infection Chapter 5: Zika virus and CNS Chapter 6: Neuropathological outcomes in human influenza and respiratory syncytial virus infections Chapter 7: The vascular route as a possible gateway for central nervous system pathology in SARS-CoV-2 infection Chapter 8: Mechanisms for entry of RNA viruses into the CNS Chapter 9: RNA sequencing as a powerful tool to capture virus-induced changes Chapter 10: Novel methods and technologies for efficient detection of RNA viruses in the human brain Chapter 11: An insight into the symptomatic treatment modalities for COVID -19 Chapter 12: Innovations in RNA therapeutics and sequencing technology to combat future viral pandemics Chapter 13: Innovative Therepeutic Efforts for Tackling Future Viral Pandemics

Sabyasachi Dash, MSc, PhD is currently a Senior Scientist in the Exploratory Research Division at Alexion-AstraZeneca Rare Disease located in New Haven, CT, USA. His work primarily focuses on drug discovery efforts for central nervous system disorders that are rare yet present a high unmet need in the society given their lack of understanding of the disease biology. He completed his postdoctoral training in neurovascular biology in the Department of Pathology and Laboratory Medicine at the Weill Cornell Medical College of Cornell University, New York, New York. His research focused on the development of novel vasoprotective therapeutics for vascular and cerebrovascular diseases by elucidating novel mechanisms regulating blood-brain barrier function in the mammalian brain. His PhD thesis work investigated the molecular mechanisms governing cocaine-induced neurotoxicity and neuroinflammation in the presence of HIV infection, which is of high pathological relevance in patients addicted to drugs of abuse.